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Humanofort Palmitoyl Oligopeptide substance

The stimulation of collagen synthesis by palmitoyl tripeptide-1
in human fibroblasts in vitro was studied.
A strong signal of collagen synthesis was noted.

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Humanofort Palmitoyl Oligopeptide substance

Palmitoyl hexapeptide-14 has been reported to stimulate cell migration, collagen synthesis, and fibroblast proliferation and scaffolding.

Order Humanofort Palmitoyl Oligopeptide substance online at the Biogenic wholesale store

About Humanofort Palmitoyl Oligopeptide

The stimulation of collagen synthesis by palmitoyl tripeptide-1 in human fibroblasts in vitro was studied. A strong signal of collagen synthesis was noted at a concentration of 0.5 μM/liter. In the same study, human skin samples were irradiated with daily doses of UVA light for one week, resulting in degradation of dermal collagen. Treatment with palmitoyl tripeptide-1 (5 ppm) during the same week caused almost total preservation and/or renewal of collagen. In another study, normal human fibroblasts were incubated in the presence of vitamin C and the following peptides: palmitoyl oligopeptide (up to 7.5 ppm), palmitoyl tetrapeptide-7 (up to 3.5 ppm), palmitoyl oligopeptide + palmitoyl tetrapeptide-7 (up to 11 ppm]), and palmitoyl pentapeptide-4 (up to 8 ppm). Except for palmitoyl oligopeptide, a dose response for collagen 1 synthesis and the de novo synthesis of fibronectin and hyaluronic acid was observed following incubation with all of the test substances. Palmitoyl hexapeptide-14 has been reported to stimulate cell migration, collagen synthesis, and fibroblast proliferation and scaffolding.

According to sources mentioned above, palmitoyl tripeptide-5 is the International Nomenclature Cosmetic Ingredient (INCI) name for L-Lysine,N-(1-oxohexadecyl)glycyl-L-histidyl (CAS No. 147732-56-7).3 However, in the International Cosmetic Ingredient Dictionary and Handbook (Dictionary), CAS No. 623172-56-5 is used to identify palmitoyl tripeptide-5, and L-Lysine,N-(1-oxohexadecyl)glycyl-L-histidyl is not listed as a technical name for this ingredient. Therefore, the CAS No. that is currently being used to identify palmitoyl tripeptide-5 needs to be confirmed. It is also noted that palmitoyl tripeptide-3 is listed as a technical name for palmitoyl tripeptide-5 in the Dictionary and that a chemical monograph on palmitoyl tripeptide-3 is not included.1 Similarly, palmitoyl tetrapeptide-3 is listed as a technical name for palmitoyl tetrapeptide-7 and palmitoyl pentapeptide-3 is listed as a technical name for palmitoyl pentapeptide-4 in the Dictionary.

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